Oncology

Authors: Phillips B, Powers BE, Dernell WS, Straw RC, Khanna C, Hogge GS, Vail DM.
Journal: JAAHA

Survival following amputation and administration of single-agent carboplatin for treatment of appendicular osteosarcoma (OSA) in dogs was retrospectively examined. Records of 155 dogs with appendicular OSA treated with amputation and single-agent carboplatin were included from 14 centers. Any carboplatin dosage, number of doses, and protocol schedule were eligible for inclusion. The median disease-free interval (DFI) was 256 days. The median overall survival time was 307 days.

Category: Oncology
Authors: Hintermeister JG, Jones PD, Hoffmann WE, Siegel AM, Dervisis NG, Kitchell BE.
Journal: AJVR

Objective-To evaluate the usefulness of carboxyterminal cross-linked telopeptide of type I collagen (ICTP) concentrations for screening dogs for the presence of osteosarcoma. Sample Population-32 client-owned dogs with osteosarcoma (27 dogs with osteosarcoma of the appendicular skeleton and 5 dogs with osteosarcoma of the axial skeleton) and 44 non-tumor-bearing control dogs. Procedures-Serum was obtained from blood samples collected from dogs with osteosarcoma and from clinically normal dogs.

Category: Biologics - Oncology
Authors: Egenvall A, Nødtvedt A, von Euler H.
Journal: Can J Vet Res

The objectives of this study were to describe the incidence of, survival until, and survival after the diagnosis of canine bone tumors by breed, sex, age, and geographic location of residence. Dogs under 10 y old and insured by a Swedish insurance company between 1995 and 2002 were studied. In total, 764 dogs had claims for bone tumors, and the incidence rate was 5.5 cases per 10 000 dog-years at risk (DYAR). At ages 6, 8, and 10 y, the proportions of dogs with bone tumors were 0.13%, 0.30%, and 0.64%. The top 3 breeds at risk were Irish wolfhound, St.

Category: Oncology
Authors: Gallegos J, Schwarz T, McAnulty JF.
Journal: JAVMA

CASE DESCRIPTION: Two 6-year-old male dogs were evaluated for removal of midline occipito-temporal multilobular osteochondrosarcomas. CLINICAL FINDINGS: Physical examination revealed mild ataxia in 1 dog and large masses of the central occipitotemporal portion of the skull in both dogs. Computed tomography, magnetic resonance imaging (MRI), or both revealed large bone-origin occipitotemporal masses with impingement of the brain and the sagittal and transverse venous sinuses.

Category: Oncology
Authors: Spugnini EP, Vincenzi B, Caruso G, Baldi A, Citro G, Santini D, Tonini G.
Journal: JSAP

A 10-year-old male intact Corso dog was referred for lameness and for a large neoplasm affecting the right foreleg. Physical examination of the patient revealed a 5 x 5 x 3 cm mass in the distal right foreleg. Histopathology was consistent with a diagnosis of appendicular osteosarcoma. The staging process found no evidence of metastasis. Because of the large size of the patient, the owners elected to treat their dog with antiresorptive therapy. The patient was treated with an infusion of zoledronic acid every 28 days.

Authors: Fitzpatrick CL, Farese JP, Milner RJ, Salute ME, Rajon DA, Morris CG, Bova FJ, Lurie DM, Siemann DW.
Journal: AJVR

OBJECTIVE: To characterize the radiosensitivity and capacity for sublethal damage repair (SLDR) of radiation-induced injury in 4 canine osteosarcoma cell lines. SAMPLE POPULATION: 4 canine osteosarcoma cell lines (HMPOS, POS, COS 31, and D17). PROCEDURES: A clonogenic colony-forming assay was used to evaluate the cell lines' intrinsic radiosensitivities and SLDR capacities. Dose-response curves for the cell lines were generated by fitting the surviving fractions after radiation doses of 0 (control cells), 1, 2, 3, 6, and 9 Gy to a linear quadratic model.

Category: Oncology
Authors: ALON KRAMER, DVM, Diplomate ACVS 1,2,3 , PETER J. WALSH, DVM, MVSc, Diplomate ACVS 1,2,3 , and BERNARD SEGUIN, DVM, Diplomate ACVS 1,2,3
Journal: Vet Surg

ABSTRACT
Objective—To review and describe the surgical procedure of hemipelvectomy in dogs and cats.
Study Design—Descriptive report.
Animals—Dogs and cats.
Methods—Anatomic surgical technique description and PubMed literature search.

Category: Oncology
Authors: JOLLE KIRPENSTEIJN, Prof., DVM, PhD, Diplomate ACVS and ECVS 1 , MARJA KIK, DVM, PhD 1 , ERIK TESKE, DVM, PhD, Diplomate ECVIM-CA 1 , and GERARD R. RUTTEMAN, DVM, PhD, Diplomate ECVIM-CA 1
Journal: Vet Surg

ABSTRACT
Objective—To investigate mutations of the TP53 gene in canine osteosarcoma (OS).
Study Design—Clinical historic cohort study.
Animals—Client-owned dogs.
Methods—OS (n=59) were screened for mutations of the complete TP53 gene using polymerase chain reaction and the mutation was analyzed by single-strand conformational polymorphism. Clinical outcome of dogs with TP53-mutated OS were compared with dogs with OS without a mutation after complete surgical excision of the primary tumor.

Category: Oncology
Authors: MARIA DIMOPOULOU, DVM 1,2 , JOLLE KIRPENSTEIJN, Prof, DVM, PhD, Diplomate ACVS & ECVS 1,2 , HESTER MOENS, DVM 1,2 , and MARJA KIK, DVM, PhD 1,2
Journal: Vet Surg

ABSTRACT
Objective—To investigate the histologic characteristics of feline osteosarcoma (OS) and compare the histologic data with phenotypically comparable canine OS. The effects of histologic and clinical variables on survival statistics were evaluated.
Study Design—Retrospective study.
Animals—Cats (n=62) and dogs (22).

Category: Oncology
Authors: Hosoya K, Poulson JM, Azuma C.
Journal: Vet Rad Ultrasound

Osteoradionecrosis and radiation-induced bone tumors are rare complications of radiation therapy. Little information regarding these complications is available in veterinary medicine. We characterized these complications and investigated risk factors in 119 dogs (122 sites) that received definitive orthovoltage radiation therapy to appendicular sites. Long-term survival was expected in all dogs. The complications of interest were osteoradionecrosis and secondary bone tumor, evaluated radiographically, histopathologically, or both.

Category: Biologics - Oncology