Oncology

Authors: Durham AC, Popovitch CA, Goldschmidt MH.
Journal: JAAHA

The histories of 67 cats diagnosed with chondrosarcoma (CSA) from 1987 to 2005 were reviewed. The mean age was 9.6 years, and males were 1.9 times more likely to be affected than females. Chondrosarcomas were diagnosed in the following sites: appendicular and axial skeleton, nasal cavity, facial bones, and extraskeletal sites. Of the 46 (70%) CSA associated with bone, 63% arose in long bones and 37% arose in flat bones. The remaining (30%) CSA arose in the subcutis.

Category: Oncology
Authors: Stefanello D, Romussi S, Signorelli P, Caniatti M, DiGiancamillo M, Roccabianca P, Avallone G.
Journal: JAAHA

An 18-month-old, female Cane Corso dog was presented with a suspected primary tumor of the tibia. Plain radiographs and computed tomography (CT) of the tibia were highly suggestive of a primary bone neoplasm. A diagnosis of malignant melanoma was made by cytology. Total body survey radiographs, CT scan of the thorax, and abdominal ultrasound excluded the presence of neoplastic lesions other than in the tibia. Limb amputation was performed.

Authors: Bacon NJ, Ehrhart NP, Dernell WS, Lafferty M, Withrow SJ.
Journal: JAVMA

Objective-To evaluate the efficacy and toxicity of an alternating carboplatin and doxorubicin chemotherapy protocol in dogs with putative microscopic metastases after amputation for appendicular osteosarcoma and assess patient-, tumor-, and treatment-related factors for associations with prognosis. Design-Retrospective case series. Animals-50 client-owned dogs.

Category: Oncology
Authors: Hosoya K, Murahari S, Laio A, London CA, Couto CG, Kisseberth WC.
Journal: AJVR

Objective-To evaluate the biological activity of dihydroartemisinin on canine osteosarcoma cell lines in vitro. Sample Population-4 canine osteosarcoma cell lines. Procedures-Cell viability assays were performed on canine osteosarcoma cell lines OSCA2, OSCA16, OSCA50, and D17 after 24, 48, and 72 hours of treatment with dihydroartemisinin at concentrations of 0.1 to 100muM. Apoptosis was assessed by use of an ELISA for free nuclosomal DNA fragmentation and by western blot analysis for cleavage of caspase 3.

Category: Biologics - Oncology
Authors: Sheahan DE, Gillian TD.
Journal: JSAP

A six-year-old border collie was presented with a solid mass on the dorsal cranium. Histological examination showed the mass to be a multilobular tumour of bone. A magnetic resonance imaging scan confirmed deformation of the dorsal cranium with compression of the cerebral hemispheres. A craniotomy was performed to excise the mass and overlying skin, resulting in a substantial deficit of calvarium and skin. A cranioplasty using a small intestinal submucosal (SIS) graft was performed to reconstruct the calvarial defect.

Authors: Novello L, Carobbi B, Bacon N, White R.
Journal: Vet Comp Orthop Traumatol.

Objective : To report the intrathecal use of a hypobaric anaesthetic solution for partial hemipelvectomy in a nine-year-old, neutered female, Golden Retriever dog, weighing 34 kg. Methods : Under inhalational anaesthesia, with the dog lying in lateral recumbency and the surgical side uppermost, 1.9 ml of a hypobaric solution containing 3.42 mg of bupivacaine and 0.66 mg of morphine were administered in the subarachnoid space at L5-6 level 30 minutes before surgery.

Authors: Kessler
Journal: EJCAP

From 1999 to 2001, 31 dogs with bone invasive tumours of the jaws were treated by maxillectomy or mandibulectomy at the Hofheim Small Animal Clinic (Germany). In addition to surgery, 3 dogs received chemotherapy, two due to metastatic spread and one after marginal resection of an extensive tumour. The goal of this study was to describe epidemiology and pathology of the various tumours, review the rate of postoperative complications and determine postoperative jaw function with regard to food and water uptake and grasping of sticks or balls.

Category: Oncology
Authors: J. Kirpensteijn
Journal: EJCAP

This is the second of two manuscripts describing osteosarcoma (OS), the most common bone tumour in dogs and cats. In this part, therapy and prognosis and the comparison between canine, and human OS is discussed.OS, a devastating disease for dogs, cats and humans, is characterised by a locally very aggressive nature and high metastatic potential. The last two decades, however, have led to significant improvements in the understanding of the pathogenesis of the disease and the success rate of different therapies.

Category: Oncology