Biologics

Authors: Stanley E Kim, Peter S McFetridge, Jennifer E Hagen

Objective: To report the successful treatment of septic nonunion in two dogs with large segmental defects secondary to long-bone fractures by using a novel human placenta-derived matrix (hPM) as adjunct to fixation.

Animals: One 3-kg 9-year-old neutered male Yorkshire terrier with a distal antebrachial fracture and one 6-kg 4-year-old spayed female miniature pinscher with a distal humeral fracture.

Authors: Metka Voga, Neza Adamic, Modest Vengust, Gregor Majdic

Regenerative medicine is a branch of medicine that develops methods to grow, repair, or replace damaged or diseased cells, organs or tissues. It has gained significant momentum in recent years. Stem cells are undifferentiated cells with the capability to self-renew and differentiate into tissue cells with specialized functions. Stem cell therapies are therefore used to overcome the body's inability to regenerate damaged tissues and metabolic processes after acute or chronic insult.

Category: Biologics
Authors: Jordi Franch, Albert Barba, Katrin Rappe, Yassine Maazouz, Maria-Pau Ginebra

Objective: To describe a novel surgical approach to treat a critical-sized bone defect due to severe, radial atrophic nonunion in a miniature dog.

Study design: Case report ANIMAL: A 1-year-old Yorkshire terrier with a critical-sized left radial defect after failed internal fixation of a transverse radial fracture.

Authors: Smith MJ, Bozynski CC, Kuroki K, Cook CR, Stoker AM, Cook JL

BACKGROUND: This study was designed to test the hypothesis that biologic scaffold augmentation of articular-sided partial-thickness supraspinatus tendon tears would be associated with superior functional, imaging, biomechanical, and histologic properties compared with untreated tears in a preclinical canine model.

Category: Biologics
Authors: Casper-Taylor ME, Barr AJ, Williams S, Wilcox RK, Conaghan PG

There is controversy over whether bone or cartilage is primarily involved in osteoarthritis (OA) pathogenesis; this is important for targeting early interventions.

Authors: Wen G, Xu J, Wu T, Zhang S, Chai Y, Kang Q, Li G.

Distraction osteogenesis (DO) is an ideal model to study bone regeneration. The major limitation is the relatively long period required for new bone consolidation.

Category: Biologics
Authors: Ferrell CL, Barnhart MD, Watson AT, Barron-Chapman ML, Naber SJ.

OBJECTIVE: To report the radiographic appearance of a bioabsorbable biocomposite tibial tuberosity advancement cage at least 1 year after implantation. Design Retrospective case series.

Category: Biologics - Stifle
Authors: Sasaki A, Mizuno M, Mochizuki M, Sekiya I

Articular cartilage damage and osteoarthritis (OA) are common orthopedic diseases in both humans and dogs. Once damaged, the articular cartilage seldom undergoes spontaneous repair because of its avascular, aneural, and alymphatic state, and the damage progresses to a chronic and painful situation. Dogs have distinctive characteristics compared to other laboratory animal species in that they share an OA pathology with humans.

Category: Biologics - Cartilage
Authors: Ying J, Han Z, Zeng Y, Du Y, Pei S, Su L, Ruan D, Chen C.

Intervertebral disc degeneration (IDD), the primary cause of low back pain, is still a great challenge to spinal surgeons and clinicians. T2 mapping, a biochemical magnetic resonance imaging (MRI) technique to calculate relaxation time, has the potential to offer a quantitative assessment of IDD.

The aim of the study was to evaluate the regenerative effects of adipose-derived mesenchymal stem cells (MSCs) encapsulated in PEGDA-microcryogels (PMs) reinforced alginate hydrogel (AH) on the degenerative intervertebral disc (IVD) in a canine model using T2 mapping.

Category: Biologics - Spine
Authors: Campos JM, et al.

Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed.