Osteoarthritis

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs

Authors: João C Alves, Ana Santos, Patrícia Jorge, P Lafuente

Objective: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.

Animals: 30 dogs.

Category: Osteoarthritis - Rehabilitation

Homing of radiolabelled xenogeneic equine peripheral blood-derived MSCs towards a joint lesion in a dog

Authors: Charlotte Beerts, Glenn Pauwelyn, Eva Depuydt, Yangfeng Xu, Jimmy H Saunders, Kathelijne Peremans, Jan H Spaas

Osteoarthritis (OA) is a highly prevalent condition in dogs, causing a substantial reduction in quality of life and welfare of the animals. Current disease management focusses on pain relief but does not stop the progression of the disease. Therefore, mesenchymal stem cells (MSCs) could offer a promising disease modifying alternative. However, little is known about the behavior and the mode of action of MSCs following their administration.

Category: Osteoarthritis

Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients

Authors: Anna R Tellegen et al.

Objective: Drug delivery platforms that allow for gradual drug release after intra-articular administration have become of much interest as a treatment strategy for OA. The aim of this study was to investigate the safety and efficacy of an intra-articular sustained release formulation containing celecoxib (CXB), a COX-2 selective inhibitor.

Category: Osteoarthritis - Pain Management

A Whole-Joint Histopathologic Grading System for Murine Knee Osteoarthritis

Authors: Caleb W Grote, Matthew J Mackay, Qinghua Lu, Xiangliang Liu, Anders R Meyer, Jinxi Wang

This study aims to develop a comprehensive and easily executable histopathologic grading scheme for murine knee osteoarthritis (OA) using specific scoring criteria for both cartilage and periarticular changes, which may overcome important limitations of the existing grading systems.

Category: Osteoarthritis

Analgesic effects and arthritic changes following tramadol administration in a rat hip osteoarthritis model

Authors: Keijiro Kanno et al.

We investigated the analgesic effects of tramadol and the arthritic changes following tramadol administration in the rat hip osteoarthritis (OA) model using mono-iodoacetate (MIA).

Category: Osteoarthritis

Defining the rate of, and factors influencing, radiographic progression of osteoarthritis of the canine hip joint

Authors: Masataka Enomoto, Elizabeth A Baines, Simon C Roe, Denis J Marcellin-Little, B Duncan X Lascelles

Background: This study aimed to define the rate of progression of radiographic osteoarthritis (OA) of the canine hip joint and to describe factors affecting this progression.

Category: Hip - Osteoarthritis

Intra-articular Injections With Either Triamcinolone Hexacetonide, Stanozolol, Hylan G-F 20, or a Platelet Concentrate Improve Clinical Signs in Police Working Dogs With Bilateral Hip Osteoarthritis

Authors: João C Alves, Ana Santos, Patrícia Jorge, Catarina Lavrador, L Miguel Carreira

Objectives: To compare the effect of intra-articular treatment with triamcinolone hexacetonide (TH), stanozolol, hyaluronan, and a platelet concentrate in police working dogs with bilateral hip osteoarthritis (OA).

Study Design: Prospective, longitudinal, double-blinded, negative controlled study.

Sample Population: Fifty police working dogs with naturally occurring hip OA.

Category: Cartilage - Osteoarthritis

Feline musculoskeletal ageing: How are we diagnosing and treating musculoskeletal impairment?

Authors: Nathalie Dowgray, Eithne Comerford

Practical relevance: An understanding of the process of musculoskeletal ageing - which all senior and geriatric cats will experience - is vital to maintaining the health and welfare of our ageing cat population.

Category: Osteoarthritis

Long-term Outcome and Progression of Osteoarthritis in Uncomplicated Cases of Cranial Cruciate Ligament Rupture Treated by TPLO in Dogs

Authors: Masakazu Shimada, Nichika Mizokam, Tom Ichinohe, Nobuo Kanno, Shuji Suzuki, Takuya Yogo, Yasuji Harada, Yasushi Hara

The object of this study is to evaluate the long-term outcome of hind limb weight-bearing function and progression of stifle osteoarthritis (OA) after tibial plateau leveling osteotomy (TPLO).

Groups were classified by the degree of cranial cruciate ligament (CrCL) damage and presence or absence of medial meniscus damage as macroscopically evaluated during surgery. Weight-bearing function was assessed via the peak vertical force (PVF), and OA progression was assessed via the radiographic OA score (OAS) preoperatively and 1, 3, 6, 12, 18, 24, and 36 months postoperatively.

Category: Hip - Osteoarthritis

Influence of orthopedic examination on lameness scores and interobserver and intraobserver agreement in dogs with naturally occurring elbow osteoarthritis

Authors: Aulakh KS, Dongaonkar KR, Barnes K, Gines AJ, Bordelon JT, Hulse D, Aulakh HK, Liu CC

OBJECTIVE: To determine the influence of orthopedic examination on numerical rating score (NRS) and visual analog score (VAS) when scoring lameness in dogs with elbow osteoarthritis (OA) and to evaluate interobserver and intraobserver agreement in NRS and VAS on the basis of video-graph

Category: Elbow - Osteoarthritis