Animal models have long been used to better understand the different diseases' mechanisms.
For many of the management options outlined in this review, there is a need for larger scale clinical trials.
Homing of xenogeneic MSCs to a naturally occurring joint lesion after IV administration.
Local sustained release of CXB is less suitable to treat acute inflammation in arthritic joints.
This reproducible scheme is easy to execute and sensitive to minimal OA progression without using computer software.