Authors: Spencer ND, Chun R, Vidal MA, Gimble JM, Lopez MJ.
Journal: Vet J

The objective of this study was to determine the tissue density, in vitro expansion and differentiation of canine adipose tissue-derived (ASC) and bone marrow-derived (BMSC) stromal cells. Primary (P0) and cell passages 1-6 (P1-6) cell doubling numbers (CD) and doubling times (DT) were determined in fresh cells. The P0, P3, and P6 adipogenic (CFU-Ad), osteogenic (CFU-Ob), and fibroblastic (CFU-F) colony forming unit frequencies, lineage specific mRNA levels in differentiated P3 cells and composition of P3 and P6 chondrogenic pellets were assessed in cryogenically preserved cells.

Authors: Buelund LE, Nielsen DH, McEvoy FJ, Svalastoga EL, Bjornvad CR.
Journal: Vet Radiol Ultrasound

Dual energy X-ray absorptiometry (DEXA) is a reference method for assessing body composition but is seldom `accessible in veterinary settings. Computed tomography (CT) can provide similar body composition estimates and we propose that it can be used in body composition studies in animals. We compared CT and DEXA data from 73 healthy adult neutered domestic cats. Three approaches for measuring adipose tissue percentage from full-body CT scans were explored.

Authors: Morton CM, Grant D, Johnston L, Letellier IM, Narbe R.
Journal: J Feline Med Surg

The aim of this study was to evaluate the efficacy and palatability of meloxicam 0.5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders. This single blinded, positively-controlled, randomised, multicentre trial involved 121 client owned cats. Cats received either meloxicam (0.5mg/ml oral suspension) at 0.1mg/kg on day 1 followed by 0.05mg/kg q 24h on days 2-5, or ketoprofen 5mg tablets at 1.0mg/kg q 24h for 5 days. The efficacy of the two treatments was assessed subjectively by clinicians on day 6 using a clinical sum score (CSS).

Authors: Laksito M, Chambers B, Hodge P, Milne M, Yates G.
Journal: Aust Vet J

Fibrotic myopathy of the iliopsoas muscle developed in a dog, following extensive migration of a grass awn within the muscle and adjacent subcutaneous tissue. The dog was initially presented for evaluation of a fluctuant swelling over the right flank region. The clinical and imaging findings were suggestive of iliopsoas fibrotic myopathy and the diagnosis was confirmed by histopathology.

Authors: Voss K, Wiestner T, Galeandro L, Hässig M, Montavon PM.
Journal: VCOT

Objectives: To assess whether fully normalised vertical ground reaction forces and stance times obtained at a trot depend on dog breed or body conformations. Methods: Peak vertical forces (PVF), vertical impulses (VI), stance times (ST), and ratio of forelimb impulse to total impulse (RVI) of 54 dogs of seven different breeds were normalised to body weight and body size according to the theory of dynamic similarity, and were tested for differences between breeds. Breeds were Borzoi, Bernese Mountain dog, Great Dane, Labrador Retriever, Landseer, Rhodesian Ridgeback, and Rottweiler.

Authors: Durant AM, Millis DL, Headrick JF.
Journal: VCOT

Objective: The purpose of the study was to evaluate the kinematic characteristics of pelvic limb joints in orthopaedically normal dogs during stair ascent. Design: Prospective study. Procedure: Eight hound-type dogs were fitted with reflective spheres at palpable landmarks, including the tuber ischium, greater trochanter, cranial dorsal iliac spine, lateral epicondyle of the femur, lateral malleolus, and the base of the fifth metatarsal bone. Each dog was walked up a set of custom made stairs consisting of four steps and then trotted across a level test space.

Authors: Stief M, Gottschalk J, Ionita JC, Einspanier A, Oechtering G, Böttcher P.
Journal: VCOT

Objectives: To report the concentration of blood cells and selected growth factors in canine autologous conditioned plasma (ACP). Methods: The density of blood cells in whole blood (WB), ACP and standard plasma preparation (SP) of 10 healthy mature dogs was determined.

Authors: Imhoff DJ, Gordon-Evans WJ, Evans RB, Johnson AL, Griffon DJ, Swanson KS.
Journal: Vet Surg

Objective: To evaluate the efficacy of S-adenosyl l-methionine (SAMe) in the treatment of clinically inferred canine osteoarthritis (OA). Study Design: Six weeks, double-blinded, placebo-controlled, clinical trial. Animals: Dogs (n=33) with clinical signs, history, and orthopedic exams consistent with OA. Methods: Dogs were block randomized by body condition score (<6/9, or ≥6/9) into either the placebo or SAMe group.

Authors: S. G. Baker (1), J. K. Roush (1), M. D. Unis (1), T. Wodiske (1)
Journal: vcot

We evaluated four measurement devices for obtaining circumferential measurements at four locations on the canine hindlimb and forelimb. We hypothesised that these devices would be consistent and precise in the hands of veterinary professionals with varying experience levels. Circumferential measurements were made in five dogs with no history or clinical evidence of orthopaedic disease. Measurements were obtained in triplicate by three observers at mid-thigh, tibial tuberosity, hock and carpus bilaterally.

Authors: Neumann S, Stolt P, Braun G, Hellmann K, Reinhart E.
Journal: JAAHA

The authors compared the symptomatic effectiveness of a complex homeopathic preparation Zeel (1-3 tablets orally per day depending on body weight) to carprofen (4 mg/kg body weight) in dogs (n=68) aged >1 yr diagnosed with osteoarthritis in a multicenter, prospective, observational open-label cohort study in 12 German veterinary clinics. The active treatment period was 56 days. Symptomatic effectiveness, lameness, stiffness of movements, and pain on palpation were evaluated by treating veterinarians and owners.