Osteoarthritis

Authors: Jorge U. Carmona and Marta Prades
Journal: Compendium Equine

Osteoarthritis (OA) in horses is a chronic, degenerative process. Affected horses typically have clinical evidence of synovitis, varying degrees of lameness, and progressive loss of joint function. The inciting cause of OA remains unclear; however, factors such as repeated episodes of trauma, joint instability, synovitis–capsulitis, hypoxia and neovascularization, genetic predisposition, and obesity have been related to its development.

Category: Equine - Osteoarthritis
Authors: Fietz, S.; Einspanier, R.; Hoppner, S.; Hertsch, B.; Bondzio, A.
Journal: Equine Veterinary Journal

Reasons for performing study: Matrix metalloproteinases (MMPs)-2 and -9 activities have been found elevated in synovial fluid from various diseased human joints. However, in the horse few data are available.

Objectives: To explore the clinical significance of MMPs-2 and -9 activities in synovial fluid of horses with different forms of joint diseases.

Category: Equine - Osteoarthritis
Authors: Lacy Kamm DVMa, Wayne McIlwraith BVSc, DACVS, PhDa and Chris Kawcak DVM, PhD, DACVS
Journal: Equine Veterinary Science

Tiludronate is a compound in the bisphosphonate class of drugs. The main pharmacologic action of bisphosphonates is to inhibit bone resorption; they cause osteoclast apoptosis and disrupt intercellular trafficking of pro-inflammatory mediators. Bisphosphonates are used to treat humans with diseases such as osteoporosis and Paget's disease. Recently tiludronate has been studied as a treatment for bone resorptive diseases in horses. Tildren, an injectable form of tiludronate made for the horse, has been licensed to treat navicular disease and distal tarsal osteoarthritis in Europe.

Authors: Antonio M. Cruz DVM, MVM, MSc, DrMedVet; Mark B. Hurtig DVM, MVSc
Journal: Veterinary Clinics Equine Practice

Osteoarthritis and articular fractures are commonly responsible for early retirement from athletic performance. The subchondral bone (SCB) in those conditions is being recognized as an integral component in their pathophysiology. Early recognition of these potentially career-ending diseases may require understanding of the progression of changes occurring in SCB with time and exercise.

Category: Equine - Osteoarthritis