OBJECTIVE: The main purpose of this study was to define criteria to systemically describe craniovertebral junction (CVJ) anomalies and to report the prevalence of CVJ anomalies in small breed dogs with and without atlantoaxial instability (AAI).
Craniovertebral Junction Anomalies in Small Breed Dogs with Atlantoaxial Instability: A Multicentre Case-Control Study
Development of a Customized Interbody Fusion Device for Treatment of Canine Disc-Associated Cervical Spondylomyelopathy
OBJECTIVES: The main purpose of this study was to design, manufacture and implant a customized three-dimensional (3D) printed, intervertebral spacer to treat disc-associated cervical spondylomyelopathy (DACSM) in dogs. This study also used advanced imaging to assess implant movement, subsidence and interbody fusion.
ANIMALS: Two client-owned dogs with DACSM.
A novel patient-specific drill guide template for stabilization of thoracolumbar vertebrae of dogs: cadaveric study and clinical cases
OBJECTIVE: To evaluate the accuracy and safety of a novel patient-specific drill guide template for stabilizing the thoracolumbar vertebrae of dogs.
STUDY DESIGN: Cadaveric experimental study and prospective case series.
The effect of body condition on postoperative recovery of dachshunds with intervertebral disc disease treated with postoperative physical rehabilitation
OBJECTIVE: To determine the impact of obesity on postoperative recovery from thoracolumbar hemilaminectomy in dachshunds treated with rehabilitation.
STUDY DESIGN: Prospective observational trial.
ANIMALS: Thirty-two dachshunds with thoracolumbar intervertebral disk disease and pain perception.
In Vitro Biomechanical Comparison of Four Different Ventral Surgical Procedures on the Canine Fourth-Fifth Cervical Vertebral Motion Unit
Introduction Biomechanical properties of four different ventral surgical procedures at the canine fourth-fifth cervical (C4–C5) vertebral motion unit (VMU) were assessed and compared with the intact C4–C5 VMU.
Determination of surgical exposure obtained with integrated endoscopic thoracolumbar hemilaminectomy in large-breed cadaveric dogs
OBJECTIVE: To define boundaries of minimally invasive integrated endoscopic hemilaminectomy at 4 sites in the canine thoracolumbar spine.
STUDY DESIGN: Experimental, randomized cadaveric study.
ANIMALS: Six cadaver dogs that had been humanely euthanized for reasons unrelated to this study.
Cervical stabilization with polyaxial pedicle screw and rod construct in horses: A proof of concept study
OBJECTIVE: To evaluate safety and efficacy of a novel technique for cervical stabilization.
STUDY DESIGN: In vivo experimental.
ANIMALS: Four normal adult quarterhorse crossbreed horses (2-4 years of age, > 250 kg).
Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model
Low back pain, related to degeneration of the intervertebral disc (IVD), affects millions of people worldwide. Clinical studies using oral cyclooxygenase-2 (COX-2) inhibitors have shown beneficial effects, although side-effects were reported. Therefore, intradiscal delivery of nonsteroidal anti-inflammatory drugs can be an alternative treatment strategy to halt degeneration and address IVD-related pain.
OBJECTIVES: To describe a surgical technique using bilateral twisted string-of-pearls locking plates for lumbosacral fracture-luxation in dogs and cats.
Notochordal cells (NCs) reside in the core of the healthy disc and produce soluble factors that can stimulate nucleus pulposus cells (NPCs). These NC-derived factors may be applied in intervertebral disc regeneration for treatment of low-back pain. However, identification of the active soluble factors is challenging. Therefore a novel approach to directly use porcine NC-rich NP matrix (NCM) is introduced.