Authors: Kon E, Robinson D, Shani J, Alves A, Di Matteo B, Ashmore K, De Caro F, Dulic O, Altschuler N

PURPOSE: The aim of this study is to investigate the safety and regenerative potential of a hemicondylar aragonite-based scaffold in the reconstruction of large osteochondral lesions occupying an extensive portion of the medial femoral condyle in a goat model.

Category: Cartilage
Authors: Olive M, Boyer C, Lesoeur J, Thorin C, Weiss P, Fusellier M, Gauthier O

OBJECTIVE: To determine the ability of three implants to enhance the healing of osteochondral defects: (1) a biphasic construct composed of calcium phosphate (CaP) and chitosan/cellulosic polymer, (2) a titanium-polyurethane implant, and (3) an osteochondral autograft.

STUDY DESIGN: Experimental study.

ANIMALS: Ten adult female sheep.

Category: Cartilage
Authors: Oliver HA, Bozynski CC, Cook CR, Kuroki K, Sherman SL, Stoker AM, Cook JL.

This study characterizes outcomes associated with subchondroplasty (SCP) versus SCP enhanced with platelet-rich plasma (PRP) or bone marrow aspirate concentrate (BMC) treatment of impact-induced subchondral bone marrow lesions (BML) using a validated preclinical canine

Category: Cartilage
Authors: Schmaranzer F1, Arendt L, Liechti EF, Nuss K, von Rechenberg B, Kircher PR, Tannast M.

BACKGROUND: Biochemical MRI of hip cartilage such as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping is increasingly used to judge cartilage quality in the assessment of femoroacetabular impingement (FAI).

Category: Cartilage
Authors: Chastain KS, Stoker AM, Bozynski CC, Leary EV, Cook JL.

PURPOSE: The objective of this study was to determine the responses of normal meniscus to collagenase activity. It was hypothesized that meniscal explants exposed to collagenase would significantly increase release of pro-inflammatory cytokines and degradative enzymes, in a dose-dependent manner, compared to control.

Category: Cartilage
Authors: Cradic DW, Aulakh KS, Hymel P, Barnes K, Gines JA, Rademacher N, Aulakh HK, Liu CC

OBJECTIVE: To determine a relationship between morphometric measurements (MM) and meniscal dimensions (MD) in the dog.

STUDY DESIGN: Cadaveric study.

ANIMALS: Eighteen mixed-breed canine cadavers (22.35 ± 4.06 kg); 36 each of medial and lateral menisci.

Category: Cartilage - Stifle
Authors: Christoph S, Bojana S, Christoph B, Manel RR, Friedrich F, Thomas K, Stefan N

The aim of this in-vitro study was to investigate the response of articular cartilage to frictional load when sliding against a metal implant, and identify potential mechanisms of damage to articular cartilage in a metal-on-cartilage pairing.

Category: Cartilage
Authors: Sasaki A, Mizuno M, Mochizuki M, Sekiya I

Articular cartilage damage and osteoarthritis (OA) are common orthopedic diseases in both humans and dogs. Once damaged, the articular cartilage seldom undergoes spontaneous repair because of its avascular, aneural, and alymphatic state, and the damage progresses to a chronic and painful situation. Dogs have distinctive characteristics compared to other laboratory animal species in that they share an OA pathology with humans.

Category: Biologics - Cartilage