Arthritis

Authors: Benito J, Depuy V, Hardie E, Zamprogno H, Thomson A, Simpson W, Roe S, Hansen B, Lascelles BD.
Journal: Vet J

The objective of this study was to test the readability, reliability, repeatability and discriminatory ability of an owner-completed instrument to assess feline degenerative joint disease (DJD)-associated pain (feline musculoskeletal pain index, FMPI). Readability was explored using four different formulas (Flesch, Fry, SMOG and FOG) and the final FMPI instrument was produced. To assess the instrument, client-owned cats that were defined as normal (normal group) or as having DJD-associated pain and mobility impairment (pain-DJD group) were recruited.

Authors: Burton NJ, Miles AW, Pollintine P.
Journal: VCOT

Objectives: To describe a novel canine castless partial carpal arthrodesis plate (par-CA) and its ex vivo biomechanical comparison with T-plate and cross pinning techniques for canine partial carpal arthrodesis. Methods: The three implant systems were applied to three cohorts of six forelimbs from Greyhounds euthanatized for reasons unrelated to the study. Intercarpal and carpometacarpal palmar fibrocartilage and ligaments were sectioned.

Authors: Gao X, Lee J, Malladi S, Melendez L, Lascelles BD, Al-Murrani S.
Journal: J Feline Med Surg

The underlying disease mechanisms for feline degenerative joint disease (DJD) are mostly unidentified. Today, most of what is published on mammalian arthritis is based on human clinical findings or on mammalian models of human arthritis. However, DJD is a common occurrence in the millions of domestic felines worldwide.

Authors: Klinck MP, Frank D, Guillot M, Troncy E.
Journal: Can Vet J

Veterinarians contacted to identify cats diagnosed with osteoarthritis (OA) provided information on signalment, method of diagnosis, treatment and concurrent disease. Owners of 50 cats were interviewed to collect information on specific OA signs observed in the home, relating to mobility, self-maintenance, social and exploratory behavior, and activity and habits at diagnosis and after treatment. Mean age at diagnosis was 12 y; concurrent diseases were common (44%).

Authors: Deluke AM, Allen DA, Wilson ER, Lineberger JA, Lehenbauer TW, Fabiani M, Poteet BA.
Journal: Can Vet J

Radiographic osteoarthritis scores were determined in 60 dogs up to 3 years following tibial plateau leveling osteotomy. Radiographs taken immediately following surgery and at long-term follow-up 1 to 3 years later were evaluated by 2 certified radiologists using a modified 32-point osteoarthritis scale. Changes in osteoarthritis scores were evaluated by paired t-tests and regression analysis. Sub-groups of dogs were formed to evaluate if osteoarthritis scores changed differently for follow-up periods of < 24 months compared with those > 24 months.

Authors: Tas O, De Cock H, Lemmens P, Pool RR.
Journal: VCOT

The clinical, radiographic and histological features of synovial osteochondromatosis in multiple joints and an unrelated sclerosing osteosarcoma of the left tibia in a cat are reported. Radiographic evaluation showed signs of several nodular radiopacities in both stifles and both shoulders. Pathologic transverse fractures of the left tibia and fibula were also present. A midfemoral amputation of the left hindlimb was performed and treatment consisted of lifelong administration of nonsteroidal anti-inflammatory drugs.

Authors: Zhang N, Dietrich MA, Lopez MJ.
Journal: Vet Surg

OBJECTIVE:
To identify the optimum intra-articular multipotent stromal cell (MSC) tissue source in the canine stifle.
STUDY DESIGN:
Experimental.
SAMPLE POPULATION:
Infrapatellar adipose tissue, synovium lining the joint capsule, and synovium surrounding the cranial cruciate ligament (CrCL) from normal stifles of 6 dogs.
METHODS:

Authors: Garner BC, Kuroki K, Stoker AM, Cook CR, Cook JL.
Journal: AJVR

Objective-To identify proteins with differential expression between healthy dogs and dogs with stifle joint osteoarthritis secondary to cranial cruciate ligament (CCL) disease. Sample-Serum and synovial fluid samples obtained from dogs with stifle joint osteoarthritis before (n = 10) and after (8) surgery and control dogs without osteoarthritis (9) and archived synovial membrane and articular cartilage samples obtained from dogs with stifle joint osteoarthritis (5) and dogs without arthritis (5).

Authors: Benito J, Gruen ME, Thomson A, Simpson W, Lascelles BD.
Journal: J Fel Med Surg

This study evaluated the types of items owners consider important to their cats' quality of life (QoL). We hypothesized that items contributing to QoL in cats are predominantly items requiring mobility.

Authors: Lo AJ, Goldschmidt MH, Aronson LR.
Journal: J Fel Med Surg

A 4-year-old castrated male Russian Blue cat was evaluated for acute right hind limb lameness 18 months after receiving a renal transplant. Radiographs showed a subluxated right femoral head and lysis of the acetabulum and femoral neck. A femoral head and neck ostectomy was performed on the right coxofemoral joint. Histologic evaluation of the right femoral head revealed lesions indicative of a chronic, granulomatous osteomyelitis and periostitis associated with an intralesional Mycobacterium species.

Category: Arthritis - Biologics