There are no experimentally validated pharmacological means of preventing laminitis; however, locally acting pharmaceutical agents with the potential to prevent laminitis have been identified. Demonstrating therapeutic drug concentrations in lamellar tissue is essential for evaluating the efficacy of these agents. The aim of this study was to develop an experimental technique for repeatedly sampling lamellar interstitial fluid. A technique for placing ultrafiltration probes was developed in vitro using 15 cadaver limbs.
Equine
Journal: The Veterinary Journal
Journal: Australian Veterinary Journal
Objective
To survey veterinary practitioners in Australia on how they administer pentosan polysulfate (PPS) to horses and their perceptions of the efficacy of PPS for: the prevention and treatment of osteoarthritis (OA), the treatment of OA when PPS is combined with other drugs, and the efficacy of PPS compared with other disease-modifying osteoarthritic drugs.
Category: Equine - Osteoarthritis - Treatment
Journal: Journal of Equine Veterinary Science
To determine the association between ultrasonographic (US) and anatomopathologic findings, an US examination was performed postmortem on the fetlock and associated structures of 37 equine forelimb specimens. All these specimens exhibited images suggestive of lesions on the ultrasound examination. Subsequently, these limbs were dissected and underwent an anatomopathologic study.
Category: Anatomic study - Equine - Traumatology - Ultrasound
Journal: Journal of Equine Veterinary Science
Degenerative joint disease (DJD) or osteoarthritis in the equine is largely a result of biomechanical stressors that result in inflammation within the joint, which with continual exposure, leads to progressive degeneration. A myriad of therapies are available for treatment of horses with DJD including nonsteroidal anti-inflammatory drugs, corticosteroids, physiological modifiers, and biological therapies.
Category: Equine - Lameness - Osteoarthritis - Treatment
Journal: Journal of Equine Veterinary Science
Twelve tarsi from six horses humanely destroyed for reasons unrelated to the study were dissected and measurements of the calcaneal insertions of the superficial digital flexor tendon (SDFT) were acquired. The medial calcaneal insertions of the SDFT ranged in length and thickness from 4.0 to 5.4 cm and 0.3 to 0.5 cm, respectively, and the lateral calcaneal insertions ranged in length and width from 4.0 to 6.3 cm and 0.3 to 0.5 cm, respectively.
Category: Equine - Tendon - Traumatology
Journal: Journal of the American Veterinary Medical Association
Objective—To determine the incidence and anatomic location of and potential risk factors for catastrophic musculoskeletal injuries (CMIs) in racing Quarter Horses.
Design—Retrospective matched case-control study.
Animals—67 racing Quarter Horse racehorses euthanized because of CMIs and 134 matched controls.
Category: Epidemiology - Equine - Traumatology
Journal: Journal of the American Veterinary Medical Association
Objective—To compare the effects of 2 approaches and 2 injection volumes on diffusion of mepivacaine hydrochloride for local analgesia of the deep branch of the lateral plantar nerve (DBLPN) in horses.
Design—Experimental study.
Animals—16 adult horses.
Category: Diagnosis - Equine - Local analgesia
Journal: American Journal of Veterinary Research
Objective—To describe the anatomic and histologic features of the collateral ligaments (CLs) of the metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joints in cadaveric limbs obtained from nonlame horses and to compare the histologic findings with the ultrasonographic appearance of the CLs.
Sample—Medial and lateral CLs of the MCP and MTP joints of 28 limbs (16 forelimbs and 12 hind limbs) from 9 adult nonlame horses euthanized for reasons unrelated to the study.
Category: Anatomic study - Equine - Imaging - Ligament - MRI
Journal: American Journal of Veterinary Research
Objective—To evaluate the efficacy and effects of labeling equine umbilical cord blood (UCB)– and bone marrow (BM)–derived multipotent mesenchymal stromal cells (MSCs) with an ultrasmall superparamagnetic iron oxide (SPIO) contrast agent and the detection of labeled MSCs by use of MRI.
Sample—UCB MSCs from placental tissues of 5 foals and BM MSCs from 5 horses.
Category: Equine - MRI - Stem cells - Tendon
Journal: Journal of the American Veterinary Medical Association
Objective—To evaluate equids with enostosis-like lesions (ELLs) and document the clinical and epidemiological features of this disease. Design—Retrospective case series. Animals—79 equids with a scintigraphic diagnosis of at least 1 ELL on ≥ 1 occasion. Procedures—Medical records of 4,992 equids that underwent bone scintigraphy between March 1997 and March 2009 were reviewed; 78 horses and 1 pony had a scintigraphic diagnosis of an ELL. For those equids, signalment; physical, scintigraphic, radiographic, and lameness examination results; and outcome were reviewed.
Category: Bone - Epidemiology - Equine