Objective: To assess the synovial fibrinolytic pathway activation in adult horses with developmental and degenerative arthropathies such as osteochondritis dissecans (OCD) and osteoarthritis (OA) by measuring synovial D-dimer concentrations. Methods: Prospective observational clinical study of horses admitted for OCD or OA.Synovial fluid was collected during lameness examination or prior to the surgical procedure, and D-dimer concentration and routine synovial fluid analysis were performed. Results: Fifty-eight horses (14 with OCD, 10 with OA and 34 controls) were included in this study. Synovial D-dimer concentrations of horses with OCD and OA were both higher when compared with controls, but were only significantly different in horses with OCD(p = 0.005). However, no statistical differences were observed when comparingsynovial D-dimer concentrations from the OCD horses with the OA-affected horses(p = 0.444).Clinical significance: Activation of coagulation and fibrinolysis play a role in the pathophysiology of equine OCD and OA.
Veterinary and Comparative Orthopaedics and Traumatology