Embryonic Stem Cells and iPS Cells: Sources and Characteristics

Authors
Catherine H. Hackett, Lisa A. Fortier
Date
August 2011
Journal
Veterinary Clinics of North America: Equine Practice
Volume
27
Number
2
Pages
233-242

The field of regenerative medicine research is rapidly expanding. One area of interest to equine researchers is the possibility of isolating or generating pluripotent cells, capable of producing differentiated cell types derived from all 3 primary germ layers. Reports of equine embryonic stem-like (ES) cell isolation can be found in the literature. Other groups are working to produce equine-induced pluripotent stem (iPS) cells. This article summarizes the essential features needed to characterize a cell type as pluripotent, specific challenges in using the horse as a model organism for pluripotent cell generation, and current and upcoming clinical trials using ES/iPS cells.

Equine
Stem cells

Related Article

The relationship between sagittal hoof conformation and hindlimb lameness in the horse
Corrective farriery to improve PADP may be investigated further as one component in the treatment of hindlimb lameness localised to regions proximal to the foot.
Use of a locking compression plate for equine proximal interphalangeal joint arthrodesis: 29 cases (2008–2014)
Surgical arthrodesis of the PIPJ was successful in most horses of the study population. Various nuances of the system for fracture repair need to be understood prior to its use.
In vitro comparison of linear vs triangular screw configuration to stabilize complete uniarticular parasagittal fractures of the proximal phalanx in horses
Triangular lag screw repair likely improves biomechanical conditions during postoperative weight bearing.
Use of an aiming device and computed tomography for assisted debridement of subchondral cystic lesions in the limbs of horses
CT-guided surgical debridement of SCL of the equine digit appears to result in a favorable outcome.
SNP-based heritability and genetic architecture of tarsal osteochondrosis in North American Standardbred horses
Future identification of the genes/variants that have the most impact on disease risk may allow early recognition of high-risk individuals.
Comparison of Metzenbaum scissors and Y-shaped fasciotome for deep metatarsal fasciotomy for the treatment of proximal suspensory ligament desmopathy in horses
A Y-shaped fasciotome may be the preferred surgical instrument for successful desmopathy of the PSL fasciotomy.